![]() ![]() Phytochrome signaling mechanisms and the control of plant development. – Van Buskirk E.K., Decker, P.V., Chen, M. (2017) Mechanism of early light signaling by the carboxy–terminal output module of Arabidopsis phytochrome B. – Qiu, Y., Pasoreck, E.K., Reddy, A.K., Nagatani, A., Ma, W., Chory, J., Chen, M. #Hemera disassembly Activator(2019) Daytime temperature is sensed by phytochrome B in Arabidopsis through a transcriptional activator HEMERA. (2019) Phytochrome activates the plastid-encoded RNA polymerase for chloroplast biogenesis via nucleus-to-plastid signaling. – Yoo, C.Y., Pasoreck, E.K., Wang, H., Cao, J., Blaha, G.M., Weigel, D., Chen, M. (2020) Increasing ambient temperature progressively disassembles Arabidopsis phytochrome B from individual photobodies with distinct thermostabilities. (2021) Direct photoresponsive inhibition of a p53-like transcriptional activation domain in PIF3 by Arabidopsis phytochrome B. – Yoo, C.Y., He, J., Sang, Q., Qiu, Y., Long, L., Kim, R.J., Chong, E., Hahm, J., Morffy, N., Zhou, P., Strader, L.C., Nagatani, A., Mo, B., Chen, X., Chen, M. These breakthroughs opened a new avenue to elucidate the mechanism of light and temperature signaling in plants and established photobody as a genetic experimental model to understand the general principles of subnuclear biomolecular condensates in cell signaling and transcriptional regulation. ![]() Our molecular genetic studies link photobodies to the regulation of the stability and activity of a group of nodal transcriptional regulators called Phytochrome-Interacting Factors (PIFs). Using forward genetic screens, we identified three novel phyB signaling components required for photobody formation, including HEMERA, RCB, and NCP. We showed that photobody localization is mediated by phyB’s C-terminal signal-output module, specifically by the dimerization/oligomerization of the histidine-kinase-like domain. ![]() Accomplishments include the determination of intrinsic phyB domains as well as extrinsic factors required for photobody formation. We aim to elucidate the mechanisms of the formation, function, and regulation of photobodies in phyB signaling and the environmental control of gene expression. When you remove the front panel, the filament, the tension pulley and the spring become a clean unit.We study how the plant photoreceptor and thermosensor phytochrome B (phyB) controls gene expression through dynamic assembly and disassembly of the phyB-containing subnuclear membraneless organelles or biomolecular condensates, named photobodies. #Hemera disassembly fullFull access allows parts to be cleaned and replaced even when filament is loaded. If you need to disassemble Hemera for maintenance, you can easily access the internal mechanisms by removing the fan and loosening the two screws on the front panel. The filament tension is increased by turning it clockwise and reduced by turning it counterclockwise. To adjust the filament tension, the user simply turns a knurled screw and a cam slide mechanism with a captive nut compresses a spring and loads the tensioning pulley. The interaction with Hemera is from above. The design of the Hemera heat sink ensures that airflow is directed up and away from both the Hot end and the heated bed, reducing the risk of warping and uneven tension in the printed part. Hemera offers practical T-slots for easy mounting on your printer as well as space for additional accessories, part fans and bed levelling probes. This exceptional system also has a significant impact on the printing of rigid and semi-rigid materials such as PLA or nylon. Only when you print ultra-flexible materials can you experience the full extent of filament delivery and reliability. Hemera extrudes filaments like no other extrusion system. #Hemera disassembly installto install slots and produce a very compact system.įilament extrusion like no other extruder It has a custom motor based on a NEMA17, as well as its own faceplate design, which allows the user to be more comfortable, e.g. The secondary gear shaft is located on a movable, sprung idler wheel that allows the user to adjust the filament tension.Į3D Hemera is a system of components that work together seamlessly as a single compact product. In fact, filaments can be pushed with up to 10 kg of force. It combines the market-leading V6 hot end with a brand new filament drive to create a responsive direct drive extrusion system that offers unprecedented performance with flexible filaments.įor E3D Hemera, E3D opted for a dual drive arrangement made of hardened stainless steel, which offers enormous grip compared to single drive systems. The E3D Hemera - formerly Hermes - is the best extrusion system that E3D has ever manufactured. ![]()
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